Chirphymium It's entirely possible that sending the audience out feeling lousy was intentional

FirstWitch A movie that not only functions as a solid scarefest but a razor-sharp satire.

Fleur Actress is magnificent and exudes a hypnotic screen presence in this affecting drama.

Billy Ollie Through painfully honest and emotional moments, the movie becomes irresistibly relatable

Mihai Toma Jones is a disgraced police cell, living inside Frank's body and trying to protect it from intruders. With the help of his new teammate, a pill recently swallowed by their host, they must fight against a very serious threat who plans to kill Frank in less than 48 hours.Contrary to my expectations, this movie isn't totally animated as the series it's based on, Frank and his miserable life being filmed in reality. It wouldn't have been such a big fuss if the actors weren't completely retarded and unpleasant, playing stupid roles in a very bad manner. Not to say that it was gross in a lot of such scenes...The story is as linear, expected and simplistic as it gets, so you'd think that it can provide something through its animated part...Well it doesn't. It's animation is O.K. but nothing more, voice acting is sometimes off while the action is boring and mostly predictable, when it's not too stupid to endure. Thankfully they thought to insert some good music throughout the picture, making the experience a bit more "enjoyable".Maybe I had high expectations from this movie as the series provided a pleasant view for me as a child, but except the two main characters, it didn't have anything for me to enjoy. Unfortunately, as a whole, it's a big letdown which I cannot recommend to anyone.

cinny85 When I first watched this film, I thought it was amazing. I have recently seen the film again and it was rather disappointing. The idea is still really good and if they'd re-film it, use more experienced people, I think it could be really good. Although the voice actors are people I really like, the performance was very poor. It all seemed to be too amateurish. Young kids, especially the boys, will still like it because it is rather disgusting. No really, it is absolutely disgusting. Under no circumstance watch this film if you are eating. It will take your appetite away.... at very least. The best thing in the film was Bill Murray, but it's a film he could have done without.

OllieSuave-007 This is a very cool live-action/animated movie starring Bill Murray as Frank Detorre, who after eating some bad food contracted a life-threatening virus. In the movie, the internal organs of Frank's body is an animated world known as the City of Frank, and is where a policeman white blood cell named Osmosis Jones (Chris Rock) and a cold pill Frank took named Drix (David Hyde Pierce) attempt to stop the virus known as Drax (Lawrence Fishburne) from claiming Frank's life.I thought this movie is very clever and imaginative, putting the human body into a whole new perspective. It makes your "insides" seem like an entire and adventurous different world, where in the film the white blood cells are law enforcement officers, lymph nodes are police stations, veins are highways, blood is water/lava, stomach is a bus station, a rowdy club is a pimple, and the germs and bacteria are the criminals.Marc Hyman wrote a fun, imaginative and adventurous script for the movie, cleverly depicting (in animation) how the human body fights infections and sickness. Brothers Bobby and Peter Farrelly did a fine job directing the film, making you suspend reality and imagining your body working like it is depicted in the film. Kudos to the team who did the animation work - bright, colorful and vibrant - nothing like some of those dull-looking and washed-out CGI animation you see nowadays. And, the live-acting and voice casting were great - realistic and believable.As this movie is raged PG, there is also quite a bit of bodily humor, puns and jokes, especially involving digestion, going to the restroom, passing gas, popping pimples from the face, food in the mouth.. (you get the drill). Therefore, you may not want to eat anything while watching this movie. But overall, it's a fun movie for both kids and adults - very entertaining! Grade B+

videodave This is one of those rare gems that gets better and better with each viewing. There are so many in-jokes and subtleties packed into it, that it is impossible to get them all with just one viewing. Each repeat viewing evokes a new and unexpected chuckle or grin. Best viewed on DVD so you can pause and review what you just thought you saw. (Does that sentence make sense?) Although the Live Action parts are rough around the edges. Bill Murray is genius, as always, and the animation scenes are obviously a work of love. The one drawback is Chris Elliot, who, no matter what project he is in, brings the whole production to a crashing bore, due to his complete unlike-ability as an actor and a person.Those who "get" this film "get it", those who don't, chances are - never will.